IUBMB Enzyme Nomenclature


Accepted name: stromelysin 2

Reaction: Similar to stromelysin 1, but action on collagen types III, IV and V is weak

Other names: matrix metalloproteinase 10; transin 2; proteoglycanase 2

Comments: In peptidase family M10 (interstitial collagenase family). Digests gelatin types I, III, IV, V, fibronectin and proteoglycan

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 140610-48-6


1. Breathnach, R., Matrisian, L.M., Gesnel, M.-C. and Leroy, P. Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Nucleic Acids Res. 15 (1987) 1139-1151. [PMID: 3547333]

2. Muller, D., Quantin, B., Gesnel, M.-C., Millon-Collard, R., Abecassis, J. and Breathnach, R. The collagenase gene family in humans consists of at least four members. Biochem. J. 253 (1988) 187-192. [PMID: 2844164]

3. Nicholson, R., Murphy, G. and Breathnach, R. Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases. Biochemistry 28 (1989) 5195-5203. [PMID: 2548603]

[EC created 1992]

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