IUBMB Enzyme Nomenclature


Accepted name: coccolysin

Reaction: Preferential cleavage: Leu, Phe, Tyr, Ala

Other names: Streptococcus thermophilus intracellular proteinase; EM 19000

Comments: A 30 kDa endopeptidase found intracellularly in Staphylococcus thermophilus [1] and S. diacetilactis [2] and in the medium of S. faecalis [3,4]. In peptidase family M4 (thermolysin family). Formerly included in EC

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 156859-08-4


1. Desmazeaud, M.J. Propriétés générales et spécificité d'action d'une endopeptidase neutre intracellulaire de Streptococcus thermophilus. Biochimie (Paris) 56 (1974) 1173-1181. [PMID: 4451671]

2. Desmazeaud, M.J. and Zevaco, C. General properties and substrate specificity of an intracellular neutral protease from Streptococcus diacetilactis. Ann. Biol. Anim. Biochem. Biophys. 16 (1976) 851-868

3. Smith, R.A.G., Green, J. and Kopper, P.H. The purification and properties of a fibrinolytic neutral metalloendopeptidase from Streptococcus faecalis. Arch. Biochem. Biophys. 202 (1980) 629-638. [PMID: 6779709]

4. Mäkinen, P.-L., Clewell, D.B., An, F., Mäkinen, K.K. Purification and substrate specificity of a strongly hydrophobic extracellular metalloendopeptidase ("gelatinase") from Streptococcus faecalis (strain 0G1-10). J. Biol. Chem. 264 (1989) 3325-3334. [PMID: 2536744]

[EC created 1972 as EC, part transferred 1992 to EC]

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