Leu, His10Leu, Ala14Leu, Tyr16Leu and Gly23Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves Ser bonds in glucagon
Reaction: Cleavage of His5Leu, His10Leu, Ala14Leu, Tyr16Leu and Gly23Phe of insulin B chain; identical to the cleavage of insulin B chain by atrolysin C. Also cleaves Ser bonds in glucagon
Other names: Crotalus atrox metalloendopeptidase b; hemorrhagic toxin b; Ht-b
Comments: From the venom of the western diamondback rattlesnake (Crotalus atrox). In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 172306-48-8
References:
1. Bjarnason, J.B. and Tu, A.T. Hemorrhagic toxins from western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e. Biochemistry 17 (1978) 3395-3404. [PMID: 210790]
2. Bjarnason, J.B., Hamilton, D. and Fox, J.W. Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom. Biol. Chem. Hoppe-Seyler 369 (1988) 121-129. [PMID: 3060135]