IUBMB Enzyme Nomenclature

EC 3.4.24.46

Accepted name: adamalysin

Reaction: Cleavage of Phe¹Val, His⁵Leu, His¹⁰Leu, Ala¹⁴Leu, Leu¹⁵Tyr, and Tyr¹⁶Leu of insulin B chain

Other names: Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II

Comments: From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α₁-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 74812-51-4

References:

1. Kurecki, T., Laskowski, M., Sr. and Kress, L.F. Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human α₁-proteinase inhibitor. J. Biol. Chem. 253 (1978) 8340-8345. [PMID: 309470]

[EC 3.4.24.46 created 1992]

Return to EC 3.4.24 home page
Return to EC 3.4 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page