IUBMB Enzyme Nomenclature


Accepted name: adamalysin

Reaction: Cleavage of Phe1Val, His5Leu, His10Leu, Ala14Leu, Leu15Tyr, and Tyr16Leu of insulin B chain

Other names: Crotalus adamanteus metalloendopeptidase; proteinase I and II; Crotalus adamanteus venom proteinase II; adamalysin II

Comments: From the venom of the eastern diamondback rattlesnake (Crotalus adamanteus). Two isoenzymes of approx. 24 kDa that inactivate α1-proteinase inhibitor by a single cleavage. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 74812-51-4


1. Kurecki, T., Laskowski, M., Sr. and Kress, L.F. Purification and some properties of two proteinases from Crotalus adamanteus venom that inactivate human α1-proteinase inhibitor. J. Biol. Chem. 253 (1978) 8340-8345. [PMID: 309470]

[EC created 1992]

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