His, Ser9His and Ala14Leu of insulin B chain and ProPhe of angiotensin I
Reaction: Cleavage of Gln4His, Ser9His and Ala14Leu of insulin B chain and ProPhe of angiotensin I
Other names: Bothrops metalloendopeptidase J; J protease
Comments: A 22.5 kDa endopeptidase from the venom of the jararaca snake (Bothrops jararaca), insensitive to phosphoramidon at 0.5 mM. In peptidase family M12 (astacin family)
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 443890-65-1
References:
1. Tanizaki, M.M., Zingali, R.B., Kawazaki, H., Imajoh, S., Yamazaki, S. and Suzuki, K. Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca). Toxicon 27 (1989) 747-755. [PMID: 2781574]