IUBMB Enzyme Nomenclature


Accepted name: ophiolysin

Reaction: Cleavage of Asn3Gln, Gln4His, His10Leu, Ala14Leu, and Tyr16Leu in insulin B chain

Other names: Ophiophagus metalloendopeptidase

Comments: A 70 kDa endopeptidase from the venom of the king cobra (Ophiophagus hannah)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: ???


1. Yamakawa, Y. and Omori-Satoh, T. A protease in the venom of king cobra (Ophiophagus hannah): purification, characterization and substrate specificity on oxidized insulin B-chain. Toxicon 26 (1988) 1145-1155. [PMID: 3070833]

[EC created 1992]

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