IUBMB Enzyme Nomenclature


Accepted name: mucrolysin

Reaction: Cleavage of Ser9His, His10Leu, Ala14Leu, Leu15Tyr and Tyr16Leu bonds in insulin B chain

Other names: Trimeresurus metalloendopeptidase A; mucrotoxin A

Comments: A 94 kDa hemorrhagic and fibrinogenolytic endopeptidase from the Chinese habu snake (Trimeresurus mucrosquamatus) venom. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 85898-38-0


1. Sugihara, H., Moriura, M. and Nikai, T. Purification and properties of a lethal, hemorrhagic protein, "mucrotoxin A", from the venom of the Chinese habu snake (Trimeresurus mucrosquamatus). Toxicon 21 (1983) 247-255. [PMID: 6857709]

2. Kishida, M., Nikai, T., Mori, N., Kohmura, S. and Sugihara, H. Characterization of mucrotoxin A from the venom of Trimeresurus mucrosquamatus (the Chinese habu snake). Toxicon 23 (1985) 637-645. [PMID: 3904081]

[EC created 1992]

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