IUBMB Enzyme Nomenclature


Accepted name: russellysin

Reaction: Specifically activates several components of the blood clotting system, including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg bonds. Has no action on insulin B chain

Other names: Russell's viper venom factor X activator; RVV-X; blood-coagulation factor X activating enzyme; metalloproteinase RVV-x; Vipera russelli proteinase; Russell's viper blood coagulation factor X activator; RVV-V

Comments: This enzyme from the venom of Russell's viper (Vipera russelli) of 79 kDa comprises a heavy (59 kDa) and a heterogeneous light (18-21 kDa) chain. Contains Ca2+ and Zn2+. The heavy chain contains the zinc-binding endopeptidase domain and a disintegrin. In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 79393-92-3


1. Furie, B.C. and Furie, B. Coagulant protein of Russell's viper venom. Methods Enzymol. 45 (1976) 191-205. [PMID: 1011991]

2. Lindquist, P.A., Fujikawa, K. and Davie, E.W. Activation of bovine factor IX (Christmas factor) by factor XIa (activated plasma thromboplastin antecent) and a protease from Russell's viper venom. J. Biol. Chem. 253 (1978) 1902-1909. [PMID: 632245]

3. Takeya, H., Nishida, S., Miyata, T., Kawada, S., Saisaka, Y., Morita, T. and Iwanaga, S. Coagulation factor X activating enzyme from Russell's viper venom (RVV-X). A novel metalloproteinase with disintegrin (platelet aggregation inhibitor)-like and C-type lectin-like domains. J. Biol. Chem. 267 (1992) 14109-14117. [PMID: 1629211]

[EC created 1993]

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