Val, His5Leu, Ala14Leu, Gly20Glu, Gly23Phe and Phe24Phe bonds in insulin B chain as well as N-blocked dipeptides
Reaction: Cleavage of Phe1Val, His5Leu, Ala14Leu, Gly20Glu, Gly23Phe and Phe24Phe bonds in insulin B chain as well as N-blocked dipeptides
Other names: Leucostoma neutral proteinase; Leucostoma peptidase A
Comments: From the venom of the western cottonmouth moccasin snake (Agkistrodon piscivorus leucostoma).
Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 72561-03-6
References:
1. Wagner, F.W., Spiekerman, A.M. and Prescott, J.M. Leucostoma peptidase A. Isolation and physical properties. J. Biol. Chem. 243 (1968) 4486-4493. [PMID: 5684005]
2. Spiekerman, A.M., Fredericks, K.K., Wagner, F.W. and Prescott, J.M. Leucostoma peptidase A: a metalloprotease from snake venom. Biochim. Biophys. Acta 293 (1973) 464-475. [PMID: 4711816]