IUBMB Enzyme Nomenclature


Accepted name: oligopeptidase A

Reaction: Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-GlyGly-Pro-Ala is cleaved, but not Z-(Gly)5 [4]

Other name(s): 68000-M signalpeptide hydrolase

Comments: Known from Escherichia coli and Salmonella typhimurium. A zinc metallopeptidase, In peptidase family M3 (thimet oligopeptidase family), but differs from thimet oligopeptidase in lack of thiol-activation

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 394250-11-4


1. Novak, P. and Dev, I.K. Degradation of a signal peptide by protease IV and oligopeptidase A. J. Bacteriol. 170 (1988) 5067-5075. [PMID: 3053642]

2. Conlin, C.A., Vimr, E.R. and Miller, C.G. Oligopeptidase A is required for normal phage P22 development. J. Bacteriol. 174 (1992) 5869-5880. [PMID: 1522065]

3. Conlin, C.A., Trun, N.J., Silhavy, T.J. and Miller, C.G. Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene. J. Bacteriol. 174 (1992) 5881-5887. [PMID: 1325967]

4. Conlin, C.A. and Miller, C.G. Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium. Methods Enzymol. 248 (1995) 567-579. [PMID: 7674945]

[EC created 1996]

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