IUBMB Enzyme Nomenclature


Accepted name: fibrolase

Reaction: Hydrolysis of -Ala14Leu- in insulin B chain and -Lys413Leu- in Aα-chain of fibrinogen

Other names: fibrinolytic proteinase; Agkistrodon contortrix contortrix metalloproteinase; Agkistrodon contortrix contortrix venom metalloproteinase

Comments: A 23-kDa, non-hemorrhagic enzyme from the venom of the southern copperhead snake (Agkistrodon contortix contortix). In peptidase family M12 (astacin family)

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, CAS registry number: 116036-70-5


1. Retzios, A.D. and Markland, F.S., Jr. A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems. Thromb. Res. 52 (1988) 541-552. [PMID: 3232124]

2. Guan, A.L., Retzios, A.D., Henderson, G.N. and Markland, F.S., Jr. Purification and characterization of a fibrinolytic enzyme from venom of southern copperhead snake (Agkistrodon contortrix contortrix). Arch. Biochem. Biophys. 289 (1991) 197-207. [PMID: 1898066]

3. Randolph, A., Chamberlain, S.H., Chu, H.L.C., Retzios, A.D., Markland, F.S. Jr. and Masiarz, F.R. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix venom. Protein Sci. 1 (1992) 590-600. [PMID: 1304358]

4. Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P. and Kuo, J. Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities. J. Chromatogr. B Biomed. Appl. 662 (1994) 227-243. [PMID: 7719479]

5. Retzios, A.D. and Markland, F.S. Fibrinolytic enzymes from the venoms of Agkistrodon contortrix contortrix and Crotalus basilicus basilicus: cleavage site specificity towards the α-chain of fibrin. Thromb. Res. 74 (1994) 355-367. [PMID: 8085237]

[EC created 1996]

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