EC 3.4.24.80

Reaction: Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at Asn³⁷Leu. Other bonds hydrolysed include Gly³⁵Ile in the propeptide of collagenase 3, and Asn³⁴¹Phe, Asp⁴⁴¹Leu and Gln³⁵⁴Thr in the aggrecan interglobular domain

Other name(s): matrix metalloproteinase 14

Comments: In peptidase family M10, but, unlike most members of the family, is membrane-anchored. Believed to play an important role in the activation of progelatinase A at cell surfaces.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 161384-17-4

References:

1. Itoh, Y., Takamura, A., Ito, N., Maru, Y., Sato, H., Suenaga, N., Aoki, T. and Seiki, M. Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion. EMBO J. 20 (2001) 4782-4793. [PMID: 11532942]