IUBMB Enzyme Nomenclature


Accepted name: ADAM10 endopeptidase

Reaction: Endopeptidase of broad specificity

Other name(s): Kuzbanian protein; myelin-associated disintegrin metalloproteinase

Comments: In peptidase family M12. Partially responsible for the "α-secretase" activity in brain that degrades the potentially harmful β-amyloid peptide. Work with ADAM10-deficient mice supports a role in Notch signalling.

Links to other databases: BRENDA, EXPASY, KEGG, MEROPS, Metacyc, PDB, CAS registry number: 193099-09-1


1. Gutwein, P., Mechtersheimer, S., Riedle, S., Stoeck, A., Gast, D., Joumaa, S., Zentgraf, H., Fogel, M. and Altevogt, D.P. ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J. 17 (2003) 292-294. [PMID: 12475894]

[EC created 2003]

Return to EC 3.4.24 home page
Return to EC 3.4 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page