IUBMB Enzyme Nomenclature


Accepted name: L-proline amide hydrolase

Reaction: (1) (S)-piperidine-2-carboxamide + H2O = (S)-piperidine-2-carboxylate + NH3
(2) L-prolinamide + H2O = L-proline + NH3

Glossary: L-pipecolate = piperidine-2-carboxylate

Other name(s): S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase; LaaA; L-amino acid amidase

Systematic name: (S)-piperidine-2-carboxamide amidohydrolase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Komeda, H., Harada, H., Washika, S., Sakamoto, T., Ueda, M. and Asano, Y. S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase. Eur. J. Biochem. 271 (2004) 1465-1475. [PMID: 15066172]

[EC created 2009]

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