Reaction: 2-oxoglutaramate + H2O = 2-oxoglutarate + NH3
Glossary: 2-oxoglutaramate = 2-ketoglutaramate = 5-amino-2,5-dioxopentanoate
Other name(s): ω-amidase (ambiguous)
Systematic name: 5-amino-2,5-dioxopentanoate amidohydrolase
Comments: The enzyme, which is highly specific for its substrate, participates in the nicotine degradation pathway of several Gram-positive bacteria.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Cobzaru, C., Ganas, P., Mihasan, M., Schleberger, P. and Brandsch, R. Homologous gene clusters of nicotine catabolism, including a new ω-amidase for α-ketoglutaramate, in species of three genera of Gram-positive bacteria. Res. Microbiol. 162 (2011) 285-291. [PMID: 21288482]