IUBMB Enzyme Nomenclature


Accepted name: 2'''-acetyl-6'''-hydroxyneomycin C deacetylase

Reaction: 2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H2O = 6'''-deamino-6'''-hydroxyneomycin C + acetate

For diagram of reaction click here.

Other name(s): neoL (gene name)

Systematic name: 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming)

Comments: Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. The enzyme from the bacterium Streptomyces fradiae also catalyses EC, 2'-N-acetylparomamine deacetylase.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Yokoyama, K., Yamamoto, Y., Kudo, F. and Eguchi, T. Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis. ChemBioChem. 9 (2008) 865-869. [PMID: 18311744]

[EC created 2012]

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