IUBMB Enzyme Nomenclature


Accepted name: γ-glutamyl hercynylcysteine S-oxide hydrolase

Reaction: γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate

For diagram of reaction click here.

Glossary: hercynine = Nα,Nα,Nα-trimethyl-L-histidine = 3-(1H-imidazol-5-yl)-2-(trimethylamino)propanoate
S-(hercyn-2-yl)-L-cysteine S-oxide = S-(N,N,N-trimethyl-L-histidin-2-yl)-L-cysteine S-oxide

Other name(s): EgtC

Systematic name: S-γ-glutamyl hercynylcysteine S-oxide amidohydrolase

Comments: The enzyme is part of the biosynthesis pathway of ergothioneine in mycobacteria.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:


1. Seebeck, F.P. In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. J. Am. Chem. Soc. 132 (2010) 6632-6633. [PMID: 20420449]

[EC created 2015]

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