Reaction: N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = 2-oxoglutarate + L-cysteinylglycine
Glossary: N-(4-oxoglutaryl)-L-cysteinylglycine = deaminated glutathione
Other name(s): dGSH deaminase; NIT1 (gene name)
Systematic name: N-(4-oxoglutaryl)-L-cysteinylglycine amidohydrolase
Comments: The enzyme, present in animals, fungi and bacteria, is involved in clearing cells of the toxic compound deaminated glutathione, which can be produced as an unwanted side product by several transaminases.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:
1. Peracchi, A., Veiga-da-Cunha, M., Kuhara, T., Ellens, K.W., Paczia, N., Stroobant, V., Seliga, A.K., Marlaire, S., Jaisson, S., Bommer, G.T., Sun, J., Huebner, K., Linster, C.L., Cooper, A.JL. and Van Schaftingen, E. Nit1 is a metabolite repair enzyme that hydrolyzes deaminated glutathione. Proc. Natl Acad. Sci. USA 114 (2017) E3233-E3242. [PMID: 28373563]