IUBMB Enzyme Nomenclature


Accepted name: [lysine-biosynthesis-protein LysW]-lysine/ornithine hydrolase

Reaction: (1) [lysine-biosynthesis-protein LysW]-C-terminal-γ-(L-ornithyl)-L-glutamate + H2O = [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-ornithine
(2) [lysine-biosynthesis-protein LysW]-C-terminal-γ-(L-lysyl)-L-glutamate + H2O = [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-lysine

Other name(s): lysK (gene name)

Systematic name: [lysine-biosynthesis-protein LysW]-C-terminal-γ-(L-ornithyl/L-lysyl)-L-glutamate amidohydrolase

Comments: The enzyme participates in L-arginine and L-lysine biosynthetic pathways in certain species of archaea and bacteria. In some organisms the enzyme also catalyses the activity of EC, [amino group carrier protein]-ornithine hydrolase.

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number:


1. Horie, A., Tomita, T., Saiki, A., Kono, H., Taka, H., Mineki, R., Fujimura, T., Nishiyama, C., Kuzuyama, T. and Nishiyama, M. Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus. Nat. Chem. Biol. 5 (2009) 673-679. [PMID: 19620981]

[EC created 2019]

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