IUBMB Enzyme Nomenclature


Accepted name: 1-carboxybiuret hydrolase

Reaction: 1-carboxybiuret + H2O = urea-1,3-dicarboxylate + NH3

For diagram of reaction click here.

Glossary: carboxybiuret = carbamoylcarbamoylcarbamic acid

Other name(s): atzEG (gene names)

Systematic name: 1-carboxybiuret amidohydrolase

Comments: The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex.

Links to other databases: BRENDA, EXPASY, ExplorEnz, KEGG, MetaCyc, CAS registry number:


1. Esquirol, L., Peat, T.S., Wilding, M., Liu, J.W., French, N.G., Hartley, C.J., Onagi, H., Nebl, T., Easton, C.J., Newman, J. and Scott, C. An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. J. Biol. Chem 293 (2018) 7880-7891. [PMID: 29523689]

[EC created 2019]

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