Reaction: guanylurea + H2O = guanidine + NH3 + CO2 (overall reaction)
(1a) guanylurea + H2O = guanidine + carbamate
(1b) carbamate = NH3 + CO2 (spontaneous)
Other name(s): guuH (gene name)
Systematic name: guanylurea amidohydrolase
Comments: The enzyme, characterized from a strain of the bacterium Pseudomonas mendocina, hydrolyses guanylurea, releasing guanidine and carbamate, which decomposes spontaneously to ammonium and CO2.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Tassoulas, L.J., Robinson, A., Martinez-Vaz, B., Aukema, K.G. and Wackett, L.P. Filling in the gaps in metformin biodegradation: a new enzyme and a metabolic pathway for guanylurea. Appl. Environ. Microbiol. 87 (2021) . [PMID: 33741630]