IUBMB Enzyme Nomenclature

EC 3.5.1.140

Accepted name: carboxyguanidine deiminase

Reaction: carboxyguanidine + H2O = urea-1-carboxylate + NH3

Glossary: urea-1-carboxylate = allophanate

Other name(s): cgdA (gene name); cgdB (gene name)

Systematic name: carboxyguanidine iminohydrolase

Comments: The enzyme, characterized from the bacterium Pseudomonas syringae, participates in the degradation of guanidine.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Schneider, N.O., Tassoulas, L.J., Zeng, D., Laseke, A.J., Reiter, N.J., Wackett, L.P. and Maurice, M.S. Solving the conundrum: widespread proteins annotated for urea metabolism in bacteria are carboxyguanidine deiminases mediating nitrogen assimilation from guanidine. Biochemistry 59 (2020) 3258-3270. [PMID: 32786413]

[EC 3.5.1.140 created 2025]


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