IUBMB Enzyme Nomenclature


Accepted name: ceramidase

Reaction: an N-acylsphingosine + H2O = a carboxylate + sphingosine

Other name(s): acylsphingosine deacylase; glycosphingolipid ceramide deacylase

Systematic name: N-acylsphingosine amidohydrolase

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37289-06-8


1. Nilsson, A. The presence of spingomyelin- and ceramide-cleaving enzymes in the small intestinal tract. Biochim. Biophys. Acta 176 (1969) 339-347. [PMID: 5775951]

2. Yavin, E. and Gatt, S. Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase. Biochemistry 8 (1969) 1692-1698. [PMID: 5805303]

[EC created 1972, modified 1990]

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