IUBMB Enzyme Nomenclature


Accepted name: 2-(acetamidomethylene)succinate hydrolase

Reaction: 2-(acetamidomethylene)succinate + 2 H2O = acetate + succinate semialdehyde + NH3 + CO2

Other name(s): α-(N-acetylaminomethylene)succinic acid hydrolase

Systematic name: 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)

Comments: Involved in the degradation of pyridoxin in Pseudomonas.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 37289-09-1


1. Huynh, M.S. and Snell, E.E. Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases. J. Biol. Chem. 260 (1985) 2379-2383. [PMID: 3972793]

2. Nyns, E.J., Zach, D. and Snell, E.E. The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of α-(N-acetylaminomethylene) succinic acid. J. Biol. Chem. 244 (1969) 2601-2605. [PMID: 5769993]

[EC created 1972]

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