IUBMB Enzyme Nomenclature


Accepted name: N-methyl-2-oxoglutaramate hydrolase

Reaction: N-methyl-2-oxoglutaramate + H2O = 2-oxoglutarate + methylamine

Other name(s): 5-hydroxy-N-methylpyroglutamate synthase

Systematic name: N-methyl-2-oxoglutaramate methylamidohydrolase

Comments: In the reverse reaction, the product cyclizes non-enzymically to 2-hydroxy-N-methyl-5-oxo-L-proline.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, CAS registry number: 9073-53-4


1. Hersh, L.B. 5-Hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action. J. Biol. Chem. 245 (1970) 3526-3535. [PMID: 5470822]

2. Hersh, L.B., Tsai, L. and Stadtman, E.R. The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid. J. Biol. Chem. 244 (1969) 4677-4683. [PMID: 5808511]

[EC created 1972]

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