IUBMB Enzyme Nomenclature


Accepted name: peptidyl-glutaminase

Reaction: α-N-peptidyl-L-glutamine + H2O = α-N-peptidyl-L-glutamate + NH3

Other name(s): peptidoglutaminase I; peptideglutaminase; peptidoglutaminase

Systematic name: peptidyl-L-glutamine amidohydrolase

Comments: Specific for the hydrolysis of the γ-amide of glutamine substituted at the α-amino group, e.g., glycyl-L-glutamine, N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 37228-70-9


1. Kikuchi, M., Hayashida, H., Nakano, E. and Sakaguchi, K. Peptidoglutaminase. Enzymes for selective deamidation of γ-amide of peptide-bound glutamine. Biochemistry 10 (1971) 1222-1229. [PMID: 4928623]

[EC created 1976]

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