IUBMB Enzyme Nomenclature


Accepted name: protein-glutamine glutaminase

Reaction: protein L-glutamine + H2O = protein L-glutamate + NH3

Other name(s): peptidoglutaminase II; glutaminyl-peptide glutaminase; destabilase; peptidylglutaminase II

Systematic name: protein-L-glutamine amidohydrolase

Comments: Specific for the hydrolysis of the γ-amide of glutamine substituted at the carboxyl position or both the α-amino and carboxyl positions, e.g., L-glutaminylglycine and L-phenylalanyl-L-glutaminylglycine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 62213-11-0


1. Kikuchi, M., Hayashida, H., Nakano, E. and Sakaguchi, K. Peptidoglutaminase. Enzymes for selective deamidation of γ-amide of peptide-bound glutamine. Biochemistry 10 (1971) 1222-1229. [PMID: 4928623]

[EC created 1976, modified 1983]

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