IUBMB Enzyme Nomenclature


Accepted name: urease

Reaction: urea + H2O = CO2 + 2 NH3

Systematic name: urea amidohydrolase

Comments: A nickel protein.

Links to other databases: BRENDA, EAWAG-BBD, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9002-13-5


1. Dixon, N.E., Gazzola, C., Blakeley, R.L. and Zerner, B. Metal ions in enzymes using ammonia or amides. Science 191 (1976) 1144-1150.

2. Sumner, J.B. Urease, in Sumner, J.B. and Myrbäck, K. (Eds.), The Enzymes, vol. 1, Academic Press, New York, 1951, pp. 873-892.

3. Varner, J.E. Urease, in Boyer, P.D., Lardy, H. and Myrbäck, K. (Eds.), The Enzymes, 2nd edn., vol. 4, Academic Press, New York, 1960, pp. 247-256.

[EC created 1961]

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