Reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine
For diagram of reaction click here.
Other name(s): kynurenine formamidase; formylase; formylkynureninase; formylkynurenine formamidase; formamidase I; formamidase II
Systematic name: aryl-formylamine amidohydrolase
Comments: Also acts on other aromatic formylamines.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 156229-75-3
References:
1. Hayaishi, O. and Stanier, R.Y. The bacterial oxidation of tryptophan. III. Enzymatic activities of cell-free extracts from bacteria employing the aromatic pathway. J. Bacteriol. 62 (1951) 691-709.
2. Jakoby, W.B. Kynurenine formamidase from Neurospora. J. Biol. Chem. 207 (1954) 657-663.
3. Mehler, A.H. and Knox, W.E. The conversion of tryptophan to kynurenine in liver. II. The enzymatic hydrolysis of formylkynurenine. J. Biol. Chem. 187 (1950) 431-438.