IUBMB Enzyme Nomenclature


Accepted name: N-malonylurea hydrolase

Reaction: 3-oxo-3-ureidopropanoate + H2O = malonate + urea

For diagram, click here

Other name(s): ureidomalonase

Systematic name: 3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming)

Comments: Forms part of the oxidative pyrimidine-degrading pathway in some microorganisms, along with EC (uracil/thymine dehydrogenase) and EC (barbiturase).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 368888-22-6


1. Soong, C.L., Ogawa, J. and Shimizu, S. Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase. Biochem. Biophys. Res. Commun. 286 (2001) 222-226. [PMID: 11485332]

2. Soong, C.L., Ogawa, J., Sakuradani, E. and Shimizu, S. Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism. J. Biol. Chem. 277 (2002) 7051-7058. [PMID: 11748240]

[EC created 2006]

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