IUBMB Enzyme Nomenclature


Accepted name: 2,5-dioxopiperazine hydrolase

Reaction: 2,5-dioxopiperazine + H2O = glycylglycine

Other name(s): cyclo(Gly-Gly) hydrolase; cyclo(glycylglycine) hydrolase

Systematic name: 2,5-dioxopiperazine amidohydrolase

Comments: Highly specific; does not hydrolyse other dioxopiperazines, glycylglycine, proteins or barbiturates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 97599-45-6


1. Suzuki, Y. and Uchida, K. Multiple forms of α-glycosidase from pig duodenum. Agric. Biol. Chem. 49 (1985) 1573-1581.

[EC created 1989]

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