Reaction: streptothricin-F + H2O = streptothricin-F acid
Other name(s): sttH (gene name)
Systematic name: streptothricin-F hydrolase
Comments: The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid . The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Maruyama, C. and Hamano, Y. The biological function of the bacterial isochorismatase-like hydrolase SttH. Biosci. Biotechnol. Biochem. 73 (2009) 2494-2500. [PMID: 19897889]
2. Hamano, Y., Matsuura, N., Kitamura, M. and Takagi, H. A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific. J. Biol. Chem. 281 (2006) 16842-16848. [PMID: 16641084]