IUBMB Enzyme Nomenclature


Accepted name: streptothricin hydrolase

Reaction: streptothricin-F + H2O = streptothricin-F acid

Other name(s): sttH (gene name)

Systematic name: streptothricin-F hydrolase

Comments: The enzyme also catalyses the hydrolysis of streptothricin-D to streptothricin-D acid [1]. The enzyme is responsible for streptothricin resistance in Streptomyces albulus and Streptomyces noursei [1,2].

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Maruyama, C. and Hamano, Y. The biological function of the bacterial isochorismatase-like hydrolase SttH. Biosci. Biotechnol. Biochem. 73 (2009) 2494-2500. [PMID: 19897889]

2. Hamano, Y., Matsuura, N., Kitamura, M. and Takagi, H. A novel enzyme conferring streptothricin resistance alters the toxicity of streptothricin D from broad-spectrum to bacteria-specific. J. Biol. Chem. 281 (2006) 16842-16848. [PMID: 16641084]

[EC created 2011]

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