Reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate
For diagram of reaction click here.
Other name(s): hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase
Systematic name: 5,6-dihydropyrimidine amidohydrolase
Comments: Also acts on dihydrothymine and hydantoin.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9030-74-4
References:
1. Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme. Arch. Biochem. Biophys. 226 (1983) 469-483. [PMID: 6639068]
2. Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes. J. Biol. Chem. 181 (1949) 449-458. [PMID: 15393763]