IUBMB Enzyme Nomenclature


Accepted name: dihydropyrimidinase

Reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

For diagram of reaction click here.

Other name(s): hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase

Systematic name: 5,6-dihydropyrimidine amidohydrolase

Comments: Also acts on dihydrothymine and hydantoin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9030-74-4


1. Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme. Arch. Biochem. Biophys. 226 (1983) 469-483. [PMID: 6639068]

2. Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes. J. Biol. Chem. 181 (1949) 449-458. [PMID: 15393763]

[EC created 1961]

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