IUBMB Enzyme Nomenclature


Accepted name: dihydroorotase

Reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

For diagram click here.

Other name(s): carbamoylaspartic dehydrase; dihydroorotate hydrolase

Systematic name: (S)-dihydroorotate amidohydrolase

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9024-93-5


1. Cooper, C. and Wilson, D.W. Biosynthesis of pyrimidines. Fed. Proc. 13 (1954) 194 only.

2. Lieberman, I. and Kornberg, A. Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. II. Dihydroorotic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin. J. Biol. Chem. 207 (1954) 911-924.

[EC created 1961]

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