IUBMB Enzyme Nomenclature


Accepted name: 5-oxoprolinase (ATP-hydrolysing)

Reaction: ATP + 5-oxo-L-proline + 2 H2O = ADP + phosphate + L-glutamate

Other name(s): pyroglutamase (ATP-hydrolysing); oxoprolinase; pyroglutamase; 5-oxoprolinase; pyroglutamate hydrolase; pyroglutamic hydrolase; L-pyroglutamate hydrolase; 5-oxo-L-prolinase; pyroglutamase

Systematic name: 5-oxo-L-proline amidohydrolase (ATP-hydrolysing)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9075-46-1


1. van der Werf, P., Orlowski, M. and Meister, A. Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the γ-glutamyl cycle. Proc. Natl. Acad. Sci. USA 68 (1971) 2982-2985. [PMID: 5289242]

[EC created 1976]

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