IUBMB Enzyme Nomenclature


Accepted name: N1-aminopropylagmatine ureohydrolase

Reaction: N1-aminopropylagmatine + H2O = spermidine + urea

For diagram of reaction click here.

Systematic name: N1-aminopropylagmatine amidinohydrolase

Comments: The enzyme, which has been characterized from the hyperthermophilic archaeon Pyrococcus kodakarensis and the thermophilic Gram-negative bacterium Thermus thermophilus, is involved in the biosynthesis of spermidine.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Ohnuma, M., Terui, Y., Tamakoshi, M., Mitome, H., Niitsu, M., Samejima, K., Kawashima, E. and Oshima, T. N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus. J. Biol. Chem. 280 (2005) 30073-30082. [PMID: 15983049]

2. Morimoto, N., Fukuda, W., Nakajima, N., Masuda, T., Terui, Y., Kanai, T., Oshima, T., Imanaka, T. and Fujiwara, S. Dual biosynthesis pathway for longer-chain polyamines in the hyperthermophilic archaeon Thermococcus kodakarensis. J. Bacteriol. 192 (2010) 4991-5001. [PMID: 20675472]

[EC created 2013]

Return to EC 3.5.3 home page
Return to EC 3.5 home page
Return to EC 3 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page