IUBMB Enzyme Nomenclature


Accepted name: guanidinobutyrase

Reaction: 4-guanidinobutanoate + H2O = 4-aminobutanoate + urea

For diagram, click here

Glossary: 4-aminobutanoate = γ-aminobutyrate = GABA

Other name(s): γ-guanidobutyrase; 4-guanidinobutyrate amidinobutyrase; γ-guanidinobutyrate amidinohydrolase; G-Base; GBH; guanidinobutyrate ureahydrolase

Systematic name: 4-guanidinobutanoate amidinohydrolase

Comments: Requires Mn2+. Also acts, very slowly, on 5-guanidinopentanoate and 6-guanidinohexanoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9013-69-8


1. Mora, J., Tarrab, R., Martuscelli, J. and Soberón, G. Characteristics of arginases from ureotelic and non-ureotelic animals. Biochem. J. 96 (1965) 588-594. [PMID: 5862400]

2. Thoai, N.V., Thome-Beau, F. and Olomucki, A. [Induction and specificity of enzymes of the new catabolic arginine pathway]. Biochim. Biophys. Acta 115 (1966) 73-80. [PMID: 5936244]

3. Yorifuji, T., Kato, M., Kobayashi, T., Ozaki, S. and Ueno, S. 4-Guanidinobutyrate amidinohydrolase from Pseudomonas sp ATCC 14676: purification to homogeneity and properties. Agric. Biol. Chem. 44 (1980) 1127-1134.

4. Yorifuji, T., Kobayashi, T., Tabuchi, A., Shiritani, Y. and Yonaha, K. Distribution of amidinohydrolases among Pseudomonas and comparative studies of some purified enzymes by one-dimensional peptide mapping. Agric. Biol. Chem. 47 (1983) 2825-2830.

[EC created 1972]

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