IUBMB Enzyme Nomenclature


Accepted name: IMP cyclohydrolase

Reaction: IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

For reaction pathway click here.

Other name(s): inosinicase; inosinate cyclohydrolase; IMP 1,2-hydrolase (decyclizing)

Systematic name: IMP 1,2-hydrolase (ring-opening)

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 9013-81-4


1. Flaks, J.G., Erwin, M.J. and Buchanan, J.M. Biosynthesis of the purines. XVIII. 5-Amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase and inosinicase. J. Biol. Chem. 229 (1957) 603-612.

[EC created 1961, modified 2000]

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