Reaction: 1-pyrroline-4-hydroxy-2-carboxylate + H2O = 2,5-dioxopentanoate + NH3
Other name(s): HPC deaminase; 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (decyclizing)
Systematic name: 1-pyrroline-4-hydroxy-2-carboxylate aminohydrolase (ring-opening)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9054-77-7
1. Singh, R.M.M. and Adams, E. Enzymatic deamination of δ1-pyrroline-4-hydroxy-2-carboxylate to 2,5-dioxovalerate (α-ketoglutaric semialdehyde). J. Biol. Chem. 240 (1965) 4344-4351.
2. Singh, R.M.M. and Adams, E. Isolation and identification of 2,5-dioxovalerate, an intermediate in the bacterial oxidation of hydroxyproline. J. Biol. Chem. 240 (1965) 4352-4356.