IUBMB Enzyme Nomenclature


Accepted name: S-methyl-5'-thioadenosine deaminase

Reaction: S-methyl-5'-thioadenosine + H2O = S-methyl-5'-thioinosine + NH3

Other name(s): MTA deaminase; 5-methylthioadenosine deaminase

Systematic name: S-methyl-5'-thioadenosine amidohydrolase

Comments: The enzyme from Thermotoga maritima also functions as S-adenosylhomocysteine deaminase (EC and has some activity against adenosine. Adenosine 5'-monophosphate and S-adenosyl-L-methionine (SAM) are not substrates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hermann, J.C., Marti-Arbona, R., Fedorov, A.A., Fedorov, E., Almo, S.C., Shoichet, B.K. and Raushel, F.M. Structure-based activity prediction for an enzyme of unknown function. Nature 448 (2007) 775-779. [PMID: 17603473]

[EC created 2011]

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