IUBMB Enzyme Nomenclature


Accepted name: 8-oxoguanine deaminase

Reaction: 8-oxoguanine + H2O = urate + NH3

Glossary: 8-oxoguanine = 2-amino-7,9-dihydro-1H-purine-6,8-dione

Other name(s): 8-OGD

Systematic name: 8-oxoguanine aminohydrolase

Comments: Zn2+ is bound in the active site. 8-Oxoguanine is formed via the oxidation of guanine within DNA by reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Hall, R.S., Fedorov, A.A., Marti-Arbona, R., Fedorov, E.V., Kolb, P., Sauder, J.M., Burley, S.K., Shoichet, B.K., Almo, S.C. and Raushel, F.M. The hunt for 8-oxoguanine deaminase. J. Am. Chem. Soc. 132 (2010) 1762-1763. [PMID: 20088583]

[EC created 2012]

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