IUBMB Enzyme Nomenclature


Accepted name: ectoine hydrolase

Reaction: ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate

Glossary: ectoine = (4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylate

Other name(s): doeA (gene name)

Systematic name: ectoine aminohydrolase

Comments: The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of N4-acetyl-L-2,4-diaminobutanoate, which is recycled back to ectoine by EC, ectoine synthase.

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Schwibbert, K., Marin-Sanguino, A., Bagyan, I., Heidrich, G., Lentzen, G., Seitz, H., Rampp, M., Schuster, S.C., Klenk, H.P., Pfeiffer, F., Oesterhelt, D. and Kunte, H.J. A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T. Environ. Microbiol. 13 (2011) 1973-1994. [PMID: 20849449]

[EC created 2017]

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