Reaction: 3',5'-cyclic AMP + H2O = 3',5'-cyclic IMP + NH3
Other name(s): cyclic adenylate deaminase; CadD
Systematic name: 3',5'-cyclic AMP aminohydrolase
Comments: Requires Zn2+. The enzyme, isolated from the bacterium Leptospira interrogans, is specific for cAMP.
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Goble, A.M., Feng, Y., Raushel, F.M. and Cronan, J.E. Discovery of a cAMP deaminase that quenches cyclic AMP-dependent regulation. ACS Chem. Biol. 8 (2013) 2622-2629. [PMID: 24074367]