IUBMB Enzyme Nomenclature


Accepted name: guanosine-5'-triphosphate,3'-diphosphate phosphatase

Reaction: guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate

Other name(s): pppGpp 5'-phosphohydrolase; guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase; guanosine pentaphosphatase; guanosine pentaphosphate phosphatase; guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase; guanosine pentaphosphate phosphohydrolase

Systematic name: guanosine-5'-triphosphate-3'-diphosphate 5'-phosphohydrolase

Comments: Also hydrolyses other guanosine 5'-triphosphate derivatives with at least one unsubstituted phosphate group on the 3'-position, but not GTP, ATP or adenosine 5'-triphosphate 3'-diphosphate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 85130-44-5


1. Hara, A. and Sy, J. Guanosine 5'-triphosphate, 3'-diphosphate 5'-phosphohydrolase. Purification and substrate specificity. J. Biol. Chem. 258 (1983) 1678-1683. [PMID: 6130093]

[EC created 1986, modified 2010]

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