IUBMB Enzyme Nomenclature


Accepted name: UDP-sugar diphosphatase

Reaction: UDP-sugar + H2O = UMP + α-D-aldose 1-phosphate

Other name(s): nucleosidediphosphate-sugar pyrophosphatase; nucleosidediphosphate-sugar diphosphatase; UDP-sugar hydrolase; UDP-sugar pyrophosphatase

Systematic name: UDP-sugar sugarphosphohydrolase

Comments: a divalent cation is required for activity. UDP-sugar is the best substrate, although other nucleoside-sugar diphosphates are used as substrates with similar Km values but much lower maximum velocities. Thus, this enzyme has a specificity distinct from that of ADP-sugar diphosphatase (EC Some but not all enzymes of this class also appear to have 5'-nucleotidase (see EC activity.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number: 55354-38-6


1. Garrett, A.R., Johnson, L.A., Beacham, I.R. Isolation, molecular characterization and expression of the ushB gene of Salmonella typhimurium which encodes a membrane bound UDP-sugar hydrolase. Mol. Microbiol. 3 (1989) 177-186. [PMID: 2548058]

2. Glaser, L., Melo, A., Paul, R. Uridine diphosphate sugar hydrolase. Purification of enzyme and protein inhibitor. J. Biol. Chem. 242 (1987) 1944-1954.

[EC created 1999]

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