IUBMB Enzyme Nomenclature


Accepted name: diphosphoinositol-polyphosphate diphosphatase

Reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate

Other name(s): diphosphoinositol-polyphosphate phosphohydrolase; DIPP

Systematic name: diphospho-myo-inositol-polyphosphate diphosphohydrolase

Comments: This enzyme hydrolyses the diphosphate bond, leaving a phospho group where a diphospho group had been. It can also act on bis(adenosine) diphosphate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Safrany, S.T., Caffrey, J.J., Yang, X., Bembenek, M.E., Moyer, M.B., Burkhart, W.A. and Shears, S.B. A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J. 17 (1998) 6599-6607. [PMID: 9822604]

2. Caffrey, J.J., Safrany, S.T., Yang, X. and Shears, S.B. Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family. J. Biol. Chem. 275 (2000) 12730-12736. [PMID: 10777568]

[EC created 2002]

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