IUBMB Enzyme Nomenclature


Accepted name: signal-recognition-particle GTPase

Reaction: GTP + H2O = GDP + phosphate

Systematic name: GTP phosphohydrolase (protein-synthesis-assisting)

Comments: Activity is associated with the signal-recognition particle (a protein- and RNA-containing structure involved in endoplasmic-reticulum-associated protein synthesis).

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Connolly, T. and Gilmore, R. The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide. Cell 57 (1989) 599-610. [PMID: 2541918]

2. Connolly, T., Rapiejko, P.J. and Gilmore, R. Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor. Science 252 (1991) 1171-1173. [PMID: 1851576]

3. Miller, J.D., Wilhelm, H., Gierasch, L., Gilmore, R. and Walter, P. GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Nature 366 (1993) 351-354. [PMID: 8247130]

4. Freymann, D.M., Keenan, R.J., Stroud, R.M. and Walter, P. Structure of the conserved GTPase domain of the signal recognition particle. Nature 385 (1997) 361-364. [PMID: 9002524]

[EC created 2000 as EC, transferred 2003 to EC]

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