IUBMB Enzyme Nomenclature


Accepted name: 2,6-dihydroxypseudooxynicotine hydrolase

Reaction: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate

For diagram of reaction click here.

Glossary: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one = 2,6-dihydroxypseudooxynicotine

Systematic name: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase

Comments: The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, PDB, CAS registry number:


1. Gherna, R.L., Richardson, S.H. and Rittenberg, S.C. The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine. J. Biol. Chem. 240 (1965) 3669-3674. [PMID: 5835946]

2. Sachelaru, P., Schiltz, E., Igloi, G.L. and Brandsch, R. An α/β-fold C—C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans. J. Bacteriol. 187 (2005) 8516-8519. [PMID: 16321959]

[EC created 2012]

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