IUBMB Enzyme Nomenclature


Accepted name: 3-fumarylpyruvate hydrolase

Reaction: 3-fumarylpyruvate + H2O = fumarate + pyruvate

Other name(s): nagK (gene name); naaD (gene name)

Systematic name: 3-fumarylpyruvate hydrolase

Comments: The enzyme is involved in bacterial degradation of 5-substituted salicylates, including gentisate (5-hydroxysalicylate), 5-nitrosalicylate and 5-halosalicylates.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Zhou, N.Y., Fuenmayor, S.L. and Williams, P.A. nag genes of Ralstonia (formerly Pseudomonas) sp. strain U2 encoding enzymes for gentisate catabolism. J. Bacteriol. 183 (2001) 700-708. [PMID: 11133965]

2. Qu, Y. and Spain, J.C. Molecular and biochemical characterization of the 5-nitroanthranilic acid degradation pathway in Bradyrhizobium sp. strain JS329. J. Bacteriol. 193 (2011) 3057-3063. [PMID: 21498645]

[EC created 2012]

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