IUBMB Enzyme Nomenclature


Accepted name: 2,4-diacetylphloroglucinol hydrolase

Reaction: 2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate

Glossary: phloroglucinol = benzene-1,3,5-triol
2,4-diacetylphloroglucinol = 1,1'-(2,4,6-trihydroxybenzene-1,3-diyl)diethan-1-one

Other name(s): PhlG

Systematic name: 2,4-diacetylphloroglucinol acetylhydrolase

Comments: Requires Zn2+. Isolated from the bacteria Pseudomonas fluorescens, Pseudomonas sp. YGJ3 and Mycobacterium abscessus 103. It reduces the antibiotic activity of 2,4-diacetylphloroglucinol.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number:


1. Bottiglieri, M. and Keel, C. Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0. Appl. Environ. Microbiol. 72 (2006) 418-427. [PMID: 16391073]

2. He, Y.X., Huang, L., Xue, Y., Fei, X., Teng, Y.B., Rubin-Pitel, S.B., Zhao, H. and Zhou, C.Z. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2,4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J. Biol. Chem. 285 (2010) 4603-4611. [PMID: 20018877]

3. Saitou, H., Watanabe, M. and Maruyama, K. Molecular and catalytic properties of 2,4-diacetylphloroglucinol hydrolase (PhlG) from Pseudomonas sp. YGJ3. Biosci. Biotechnol. Biochem. 76 (2012) 1239-1241. [PMID: 22790955]

4. Zhang, Z., Jiang, Y.L., Wu, Y. and He, Y.X. Crystallization and preliminary X-ray diffraction analysis of a putative carbon-carbon bond hydrolase from Mycobacterium abscessus 103. Acta Crystallogr. F Struct. Biol. Commun. 71 (2015) 239-242. [PMID: 25664803]

[EC created 2019]

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